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Xeroderma pigmentosum Bilder

Browse 67 xeroderma pigmentosum stock photos and images available, or start a new search to explore more stock photos and images. Xeroderma Pigmentosum, a rare genetic disease - Twins hide to survive in France in October 2001 - In their house transformed into a forced.. Xeroderma pigmentosum images — codes and concepts. open. Synonyms: Pictures of XP. Categories: Genetic disorder, Systemic disorder, Images. Subcategories: Xeroderma pigmentosum in pigmented skin

Xeroderma Pigmentosum Photos and Premium High Res Pictures

  1. Xeroderma pigmentosum Bilder : Mycket sällsynt hudsjukdom där en person är mycket känslig för solljus och är benägen att utveckla hudcancer, orsaker, symptom, behandling, bilder
  2. Xeroderma pigmentosum, är en autosomal recessiv genetisk sjukdom där DNA:s reparationssystem är muterat, och inte längre effektivt kan reparera DNA-skador till följd av ultaviolett ljus (UV). [1] I sjukdomens mest extrema form är all exponering för solljus förbjuden, oavsett hur lite
  3. Xeroderma pigmentosum: 43-Jahre alter irakisch geborener Patient mit poikilodermatischer Haut, mit flächigen und fleckigen Pigmentierungen in den sonnenbelichteten Arealen an Wange und im Halsbereich. Vorbehandelt wurden zahreiche Bsalzellkarzinome v.a. im Bereich der Nase (s. Defektheilung)
  4. utes in the sun, freckling in sun exposed areas, dry skin and changes in skin pigmentation. Nervous system problems, such as hearing loss, poor coordination, loss of intellectual function and seizures, may also occur. Complications include a high risk of skin cancer, with about.
  5. Xeroderma pigmentosum är en allvarlig genetisk sjukdom som leder till en kraftig reduktion av livslängden. Personer drabbade av sjukdomen tvingas leva i ständigt skydd från solljus och artificiella ljuskällor på grund av en extrem känslighet för UV-strålning. Exponering för UV-strålning leder till stor risk för hudcancer

Xeroderma pigmentosum images DermNet N

xeroderma pigmentosum. 5 likes · 6 talking about this. Mental Health Servic Xeroderma pigmentosum; Arsenik; Strålbehandling av godartade förändringar i huden, exempelvis tinea capitis eller hemangiom (numera ej vanlig praxis) Kroniska sår (sällsynt) SYMTOM OCH KLINISKA FYND . Patienten kan uppvisa en knuta, en eksemliknande fläck eller ett sår som inte vill läka

Xeroderma pigmentosum : Bilder, diagram, illustrationer

1882 - Kaposi expounded on the essential role of the pigment abnormalities' in the disease and suggested the name Xeroderma pigmentosum. In addition to the parchment-like dryness, thinness, and wrinkling of the epidermis, the checkered pigmentation, and the small dilatations of the vessels, the most remarkable symptoms were the contraction and, at the same time, thinning of the skin Xeroderma Pigmentosum, a rare genetic disease - Twins hide to survive in France in October 2001 - On their way back from judo training, Vincent and... pearl - sport rare bildbanksfoton och bilder Bowhead whales and a SUP surfer in the Vrangel Bay, 50km of the southern border of the Shantar Islands National Park Xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner. It is characterized by photosensitivity, pigmentary changes, premature skin aging, and malignant tumor development. [ 2 Xeroderma pigmentosum, or XP, is a rare hereditary disease where patients are unable to repair the cellular damage caused by ultraviolet light.To learn more.

Xeroderma pigmentosum - Wikipedi

  1. Most people with xeroderma pigmentosum develop multiple skin cancers during their lifetime. These cancers occur most often on the face, lips, and eyelids. Cancer can also develop on the scalp, in the eyes, and on the tip of the tongue. Studies suggest that people with xeroderma pigmentosum may also have an increased risk of other types of cancer, including brain tumors
  2. Xeroderma pigmentosum (XP) on hyvin harvinainen sairaus, joka kuvattiin ensi kertaa vuonna 1874.Oireisto on peittyvästi periytyvä. Se aiheuttaa ihon kuivumisen ja pigmentoitumisen. Sairaus puhkeaa varhaisella iällä, sillä se havaitaan tyypillisesti lapsen ollessa 1-2-vuotias
  3. Xeroderma pigmentosum ist eine Hautkrankheit, die auf einem genetischen Defekt beruht und den Chromosomenbruchsyndromen zuzuordnen ist. Sie ist eine sehr seltene Krankheit, regional unterschiedlich liegt die Häufigkeit zwischen 1:40.000 und 1:250.000; in den USA leben ungefähr 250 Menschen mit dokumentierter XP, in Deutschland etwa 80, die meisten davon sind Kinder. Die Lebenserwartung dieser Patienten ist unbehandelt gering, in der Regel sterben sie im ersten Lebensjahrzehnt.
  4. Tema presentado por Cervantes Álvarez Claudia Karolina, Tejada Baldenebro Rogelio de Jesùs y Urquidez Osuna Erik Daniel, alumnos de la asignatura de Bioquími..
  5. Xeroderma pigmentosum - er en meget sjælden hudsygdom, hvor en person er meget følsom over for sollys (lysfølsom).En tidlig aldring af huden og er tilbøjelig til at udvikle hudkræft. Dette er forårsaget af cellulære overfølsomhed over for ultraviolet (UV) på grund af en defekt i DNA-reparation system
  6. Bei Bestrahlung der Haut durch UV-Strahlen kommt es zu pathologischen Veränderungen. Moritz K. Kaposi beschrieb 1870 erstmals diese Dermatose als Xeroderma (Pergamenthaut) 1882 ergänzte er pigmentosum auf Grund der Pigmentabnormalität. See full transcript
  7. XPB (Xeroderma Pigmentosum B) je ATP zavisna ljudska DNK helikaza koja je deo kompleksa TFIIH transkripcionog faktora. 3D struktura XPB homologa je kristalografski

Xeroderma pigmentosum Images - Altmeyers Encyclopedia

Xeroderma Pigmentosum can be defined as a genetic pathological condition of the autosomal recessive form in which the body loses its ability to repair damage caused to the body by the ultraviolet rays of the sun. In acute cases, the affected individual is required to completely stay away from sunlight Xeroderma pigmentosum (XP) is a rare inherited skin disorder characterized by a heightened sensitivity to the DNA damaging effects of ultraviolet radiation (UV). The main source of UV is the sun. The symptoms of XP can be seen in any sun-exposed area of the body Xeroderma pigmentosum, Cockayne-Syndrom und Trichothiodystrophie sind seltene, autosomal-rezessive Genodermatosen mit einem klinisch heterogenen Bild. Die ersten Krankheitssymptome treten in der Regel bereits im frühen Kindesalter auf. Alle drei Erkrankungen sind durch Photosensitivität und einen Reparaturdefekt von UV-induzierten DNS-Schäden gekennzeichnet

Xeroderma pigmentosum was described for the first time in 1870 in Vienna by Moritz Kaposi, a Hungarian professor of dermatology and in 1874 was named for the first time Xeroderma or parchment skin, while in 1882, the term 'pigmentosum' had been added to emphasize the striking anomaly of pigmentation XERODERMA PIGMENTOSUM (XP) What are the aims of this leaflet? This leaflet has been written to help you understand more about xeroderma pigmentosum (XP). It tells you what it is, what causes it, what can be done about it and where you can find out more. What is XP? XP is a very rare condition with about 100 patients living with it in the UK. X Xeroderma Pigmentosum definition A rare autosomal recessive disease characterized by photosensitivity, photodamage, cutaneous malignancies, severe ophthalmological abnormalities and often early death from malignancy.This light-provoked disease can affect all races

The XPA protein (xeroderma pigmentosum group complementation group A) consists of 273 amino acids (31 kDa) and can occur as either a homodimer or in complex with other NER proteins (Liu et al. Reference Liu, Yang, Utzat, Wang, Basu and Zou 2005; Yang et al. Reference Yang, Liu, Mao, Zhang and Zou 2002) Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of DNA repair characterized by increased sensitivity to ultraviolet radiation (UVR), early de A newly identified patient with clinical xeroderma pigmentosum phenotype has a non-sense mutation in the DDB2 gene and incomplete repair in (6-4) photoproducts. J Invest Dermatol, 113 (1999), pp. 251-257. Article Download PDF View Record in Scopus Google Scholar. Jerbi et al., 2016

Xeroderma pigmentosum

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Several genetic disorders caused by defective nucleotide excision repair that affect the skin and the nervous system have been described, including Xeroderma Pigmentosum (XP), De Sanctis-Cacchione syndrome (DSC), Cockayne syndrome, and Trichothiodystrophy. Cutaneous photosensitivity with an increased risk of skin malignancy is a common feature of these disorders, but clinical manifestations. Aging results from intrinsic changes (chronologic) and damage from external exposures (extrinsic) on the human body. The skin is ideal to visually differentiate their unique features. Inherited diseases of DNA repair, such as xeroderma pigmentosum (XP), provide an excellent model for human aging due to the accelerated accumulation of DNA damage Xeroderma Pigmentosum is caused by a defect in one of the genes that is responsible for repairing cell damage caused by UV light. This defect leads to cancerous cells or cell death It is an autosomally recessive inherited disease Xeroderma pigmentosum (XP) is a form of general dermatosis characterised by photo-induced cutaneous-ocular impairment and by skin cancers. In addition to these signs, there may also be neurological involvement

Xeroderma pigmentosum (XP) is an autosomal recessive photosensitive disorder with an extremely high incidence of UV‐related skin cancers associated with impaired ability to repair UV‐induced DNA damage. There are seven nucleotide excision repair (NER) complementation groups (A through G) and an NER proficient form (XP variant) Xeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis that results due to mutations in nucleotide excision repair. The condition characteristically demonstrates severe photosensitivity, skin pigmentary changes, malignant tumor development, and occasionally progressive neurologic degeneration Alex Webb was 4 years old when he was diagnosed with xeroderma pigmentosum nine years ago. This is his story as told by his mother. His parents established a support group that is now widely recommended by consultant dermatologists My son Alex was diagnosed with xeroderma pigmentosum at the age of 4 years. He was born in Germany and lived there for the first two years of his life

Xeroderma Pigmentosum (XP) is a rare autosomal recessive disorder characterized by photosensitivity with easy skin burning following minimal sun exposure, pigmentary changes, premature skin aging and predisposition to malignant tumor development.These features result from a defect in DNA repair mechanisms after exposure to ultraviolet (UV) radiation Xeroderma Pigmentosum (XP) is a rare autosomal recessive disorder characterized by photosensitivity with easy skin burning following minimal sun exposure, pigmentary changes, pre It is effective in Xeroderma pigmentosum as it acts as a natural Rejuvenator for skin and also provides relief from skin inflammation and irritation. Ashwagandha herb helps to balance the Vata dosha in the body. Dosage: 2 capsules two times daily with plain water after meals. 2 Unusual changes in the melanin pigmentary system were observed on a warty papule biopsy taken from a patient with xeroderma pigmentosum (XP). Degenerated melanocytes full of lipids were observed from the basal layer up to the middle of the epidermis. The melanosomes were polymorphous, variable in size and shape with very strange aspects, such as spider-like and whirling configurations

Xeroderma pigmentosum is a rare inherited condition marked by extreme sensitivity to sunlight and greatly increased incidence of skin and eye cancers Xeroderma pigmentosum is a very rare condition that affects approximately 1 in every 250,000 people on average globally. It is less common in Europe and in the United States, where it will affect just 1 person in every 1 million Nucleotide-excision repair diseases exhibit cancer, complex developmental disorders and neurodegeneration. Cancer is the hallmark of xeroderma pigmentosum (XP), and neurodegeneration and. Xeroderma Pigmentosum M.L. Kulkarni. K. saniay Kani Xeroderma pigmehtosum (XP) is a rare autosomal recessive disorder associated with defective DNA repair which causes photosensitivity. The photosensitivity leads to pigmentary changes, atrophy and later squamous cell carcinoma of the skin(l). So fa

Xeroderma Pigmentosum Stock-Fotos und Bilder - Getty Images

Xeroderma pigmentosum (XP); Orpha 910 Definition Xeroderma pigmentosum (literally dry pigmented skin), is defined by extreme sensitivity to sunlight, resulting in sunburn, pigment changes in the skin and a greatly ele-vated incidence of skin cancers. About 60% of affected individuals show an exaggerated and prolonged sunburn response Xeroderma pigmentosum (XP) is a genetic condition that causes severe sensitivity to UV light. Here, learn about the symptoms, causes, and management options The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and.

What is xeroderma pigmentosum. Xeroderma pigmentosum has also been called DeSanctis-Cacchione syndrome, is a very rare inherited skin disorder where a person is extremely sensitivity to ultraviolet (UV) rays from sunlight, has premature skin ageing and is prone to developing skin cancers XP patients are susceptible to UV-induced freckling and malignant skin changes, whereas Cockayne syndrome (see, e.g., 216400) patients do not have increased susceptibility to these lesions. Seguin et al. (1988) studied the frequency of ultraviolet light-induced chromosomal breaks in lymphoblastoid cell lines from patients with Cockayne syndrome and from patients with xeroderma pigmentosum Xeroderma pigmentosum (XP) is defined by extreme sensitivity to sunlight, resulting in sunburn, pigment changes in the skin and a greatly elevated incidence of skin cancers Xeroderma pigmentosum (XP) is characterized by: Sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure in ~60% of affected individuals), with marked freckle-like pigmentation of the face before age two years in most affected individuals; Sunlight-induced ocular involvement (photophobia, keratitis, atrophy of the skin of the lids); Greatly increased risk of. Xeroderma pigmentosum är en sjukdom där drabbade individer är hyperkänsliga för ultraviolett ljus. Känsligheten leder till 1000 ggr högre risk för hudcancer, 2000 ggr högre risk för neoplasm i ögonen samt neurologiska problem. Sjukdomen tvingar drabbade individer att leva skyddade från ultraviolett ljus

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High prevalence of the point mutation in exon 6 of the xeroderma pigmentosum group A-complementing (XPAC) gene in xeroderma pigmentosum group A patients in Tunisia. Nishigori C, Zghal M, Yagi T, Imamura S, Komoun MR, Takebe H: American journal of human genetics. 1993 ; 53 (5) : 1001-1006. PMID 810568 Daya-Grosgean, L. Xeroderma pigmentosum and skin cancer. Adv Exp Med Biol. vol. 637. 2008. pp. 19-27. (A detailed discussion of the molecular basis of XP is presented with sections on tumor suppressor genes, oncogenes and the impaired immune system.) Giordano, CN, Yew, YW, Spivak, G, Lim, HW Xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner. [1] It is characterized by photosensitivity, pigmentary changes, premature skin aging, and malignant tumor development. [2] These manifestations are due to a cellular hypersensitivity to ultraviolet (UV) radiation resulting from a defect in DNA repair Xeroderma pigmentosum (XP) is a hereditary autosomal recessive disorder characterized by photo hypersensitivity of sun exposed tissues and subsequent several-fold increased risk for malignant changes resulting from impaired ability to repair UV-induced DNA damage. Estimated incidences vary from 1 in 20,000 in Japan to 1 in 250,000 in the USA, and approximately 2.3 per million live births in. Xeroderma Pigmentosum Xeroderma pigmentosum Engelsk definition. A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA

Natália Cestari Moreno, Tiago Antonio de Souza, Camila Carrião Machado Garcia, Nathalia Quintero Ruiz, Camila Corradi, Ligia Pereira Castro, Veridiana Munford, Susan Ienne, Ludmil B Alexandrov, Carlos Frederico Martins Menck, Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells, Nucleic Acids Research, Volume 48, Issue 4, 28 February. Xeroderma pigmentosum (literally dry pigmented skin) is dened by extreme sensitivity to sunlight, resulting in sun- burn,pigmentchangesintheskin,andagreatlyelevatedinci A number sign (#) is used with this entry because of evidence that xeroderma pigmentosum complementation group G (XPG) and XPG/Cockayne syndrome are caused by homozygous or compound heterozygous mutation in the ERCC5 gene on chromosome 13q33.Homozygous mutation in the ERCC5 gene can also cause cerebrooculofacioskeletal syndrome-3 (COFS3; 616570)

Valid for Submission. Q82.1 is a billable diagnosis code used to specify a medical diagnosis of xeroderma pigmentosum. The code Q82.1 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions Xeroderma pigmentosum is an autosomal recessive disease caused by mutations in at least eight different genes, including XPA, XPC, and ERCC5.2,4-6 ,An individual who has one mutation in any of these genes is a carrier and is not expected to have related health problems

Xeroderma pigmentosum • LITFL Medical Blog • Medical

Xeroderma pigmentosum defines a class of autosomal recessive inherited diseases that are characterized clinically by sun sensitivity that results in progressive degeneration of sun exposed areas of the skin and eyes. Often these changes will result in neoplasia Xeroderma pigmentosum (XP) is a hereditary condition characterized by extreme sun sensitivity, leading to a very high risk of skin cancer and other medical problems. People with XP are extremely sensitive to ultra-violet (UV) radiation from the sun A rare, pigmentary, and atrophic autosomal recessive disease affecting all races. It is manifested as an extreme photosensitivity to ultraviolet light as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA Xeroderma Pigmentosum (XP) is a rare genetic disorder that occurs worldwide in all races and ethnic groups. First described by Hebra and Kaposi in 1874 the disorder is characterised by marked photosensitivity and premature onset of all major types of skin cancer [1] The disease xeroderma pigmentosum is characterized by deficient repair of damaged DNA. Fusions of cells from different patients have defined nine genetic complementation groups (A through I), implying that DNA repair in humans involves multiple gene products. In this report, an extension of the gel electrophoresis binding assay was used to identify at least one nuclear factor that (i) bound to.

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Xeroderma Pigmentosum: Background, Pathophysiology

Xeroderma pigmentosum, rare, recessively inherited skin condition in which resistance to sunlight and other radiation beyond the violet end of the spectrum is lacking. On exposure to such radiation the skin erupts into numerous pigmented spots, resembling freckles, which tend to develop int Xeroderma pigmentosum (XP) is a rare disorder. It is a genetic disorder. This means that people have a problem in a specific gene or genes. People have about 20,000-25,000 genes in their bodies. Genes are like our body's instruction manual - they control the growth, development and normal function

Xeroderma pigmentosum is an autosomal recessive disorder in which the individual is left essentially unprotected from ionizing radiation. The mechanism is well understood and involves the absence. Xeroderma Pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. Symptoms may include a severe sunburn after only a few minutes in the sun, freckling in sun exposed areas, dry skin and changes in skin pigmentation A young couple's life changes after discovering that their two young daughters have Xeroderma Pigmentosum, which makes them vulnerable for sunlight. Director: Michael Switzer | Stars: Peter Horton, Tracy Pollan, Roy Dotrice, Bill Smitrovich. Votes: 19

XP, Xeroderma Pigmentosum: Wenn Sonnenlicht tödlich sein

National Xeroderma Pigmentosum Service, St John's Institute of Dermatology Guy's and St Thomas' Foundation Trust, London, UK. Correspondence. Paola Giunti, Ataxia Centre, Department of Clinical and Movement Neurosciences, University College London, Institute of Neurology London, London WC1N 3BG, UK. E‐mail: p.giunti@ucl.ac.u The Xeroderma Pigmentosum (XP) Family Support Group exists to improve the quality of life for people with XP and other diagnosed UV light conditions. The Xeroderma Pigmentosum Family support group strives to create awareness and educate the public about XP, as well as to raise funds to promote research, create collaborations with international XP partner organizations, and provide family. Inlägg om xeroderma pigmentosum skrivna av Bitchslap Barbie. Egentligen har jag inte alls tid att skriva nåt här, jag borde sminka mig och sen packa ner sminket och gå till skolan som en duktig student Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system. Kazantsev A, Mu D, Nichols AF, Zhao X, Linn S, Sancar A Proceedings of the National Academy of Sciences of the United States of America. 1996 ; 93 (10) : 5014-5018

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Xeroderma pigmentosum. More than 40 mutations in the XPC gene have been found to cause xeroderma pigmentosum. Mutations in this gene are the most common cause of this disorder in the United States and Europe. Most XPC gene mutations prevent the production of any XPC protein Xeroderma Pigmentosum: Causes, Risks & Screening. Published : 2015-08-19 Author : Thomas C. Weiss - Contact: Disabled World. Synopsis*: Information regarding Xeroderma pigmentosum, a condition characterized by extreme sensitivity to the sun, leading to high risk of skin cancer

Xeroderma pigmentosum is a rare, genetic condition that can lead to defective DNA repair, a side effect that has encouraged researchers to further investigate the clinical characteristics of this condition. Dr. Michael Greenberg meets with Dr. Kenneth Kraemer to discuss his study on xeroderma pigmentosum Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by a high incidence of skin cancers. Yeast RAD30 encodes a DNA polymerase involved in the error-free bypass of ultraviolet (UV) damage. Here it is shown that XP variant (XP-V) cell lines harbor nonsense or frameshift mutations in hRAD30 , the human counterpart of yeast RAD30

Basalzellkarzinom – Therapieoptionen für den häufigsten

Abstract. Xeroderma pigmentosum group C (XP-C) is a rare autosomal recessive disorder. Patients with two mutant alleles of the XPC DNA repair gene have sun sensitivity and a 1000-fold increase in skin cancers. Clinically normal parents of XP-C patients have one mutant allele and one normal allele Xeroderma pigmentosum: A genetic disease that is characterized by such extraordinary sensitivity to sunlight that it results in the development of skin cancer at a very early age. Abbreviated XP. Children with XP can only play outdoors safely after nightfall. XP is due to defective repair of damage done to DNA by ultraviolet (UV) light Find all the evidence you need on Xeroderma pigmentosum via the Trip Database. Helping you find trustworthy answers on Xeroderma pigmentosum | Latest evidence made eas Xeroderma pigmentosum (XP) is a rare genetic disorder that causes extreme sensitivity to ultraviolet rays (UV). In any individual, when excessive UV light hits the skin, it has the ability to produce genetic mutations in the DNA in skin cells

Hautkrankheiten: "Mondscheinzwillinge" haben selteneMondscheinkrankheit XP: Sonne zerfrisst Dorfbewohner inUniversitätshautklinik - Hautkrebsvorstufen

Fanconi anemia (FA) is an inherited genomic instability disorder with congenital and developmental abnormalities, bone marrow failure and predisposition to cancer early in life, and cellular sensitivity to DNA interstrand crosslinks. A fifty-one-year old female patient, initially diagnosed with FA in childhood on the basis of classic features and increased chromosomal breakage, and remarkable. Gene therapy for xeroderma pigmentosum is still in a theoretical and experimental stage. Surgery; The malignancies associated with xeroderma pigmentosum should be completely excised. Prognosis; Less than 40% of individuals with the disease survive beyond the age of 20. Some XP victims with less severe cases do manage to live well into their 40s Xeroderma Pigmentosum Group D Protein Xeroderma pigmentosum grupp D-protein Engelsk definition. A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM Xeroderma Pigmentosum: Synonyms Kaposi Disease | Kaposi's Disease | Kaposis Disease | XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP A.

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